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Article

A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens.

BMC medicine - 1 Dec 2021

Liu Wei, Johansson Åsa, Rask-Andersen Helge, Rask-Andersen Mathias

Abstract excerpt

BACKGROUND: Sensorineural hearing loss is one of the most common sensory deficiencies. However, the molecular contribution to age-related hearing loss is not fully elucidated. METHODS: We performed genome-wide association studies (GWAS) for hearing loss-related traits in the UK Biobank (N = 362,396) and selected a high confidence set of ten hearing-associated gene products for staining in human cochlear samples:...

Topics

Cochlea
Genome-Wide Association Study
Hearing Loss
Hearing Loss, Sensorineural
Humans
Phenotype
Trans-Activators
Ubiquitin-Protein Ligases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34847940
DOI: 10.1186/s12916-021-02169-0
PMCID: PMC8638543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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