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Article

Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Jul 2016

Yang Yang, Huang Jianying, Mis Malgorzata A, Estacion Mark, Macala Lawrence, Shah Palak, Schulman Betsy R, Horton Daniel B, Dib-Hajj Sulayman D, Waxman Stephen G

Abstract excerpt

UNLABELLED: Voltage-gated sodium channel Nav1.7 is a central player in human pain. Mutations in Nav1.7 produce several pain syndromes, including inherited erythromelalgia (IEM), a disorder in which gain-of-function mutations render dorsal root ganglia (DRG) neurons hyperexcitable. Although patients with IEM suffer from episodes of intense burning pain triggered by warmth, the effects of increased temperature on...

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Identifiers

PMID: 27413160
DOI: 10.1523/JNEUROSCI.0462-16.2016
PMCID: PMC6705539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli.PMID 27413160Read ↗

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