Article
A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons.
Proceedings of the National Academy of Sciences of the United States of America - 23 May 2006
Rush Anthony M, Dib-Hajj Sulayman D, Liu Shujun, Cummins Theodore R, Black Joel A, Waxman Stephen G
Abstract excerpt
Disease-producing mutations of ion channels are usually characterized as producing hyperexcitability or hypoexcitability. We show here that a single mutation can produce hyperexcitability in one neuronal cell type and hypoexcitability in another neuronal cell type. We studied the functional effects of a mutation of sodium channel Nav1.7 associated with a neuropathic pain syndrome, erythermalgia, within sensory...
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