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Lsr2 Is an Important Determinant of Intracellular Growth and Virulence in Mycobacterium abscessus

30 Apr 2019

Abstract excerpt

Mycobacterium abscessus, a pathogen responsible for severe lung infections in cystic fibrosis patients, exhibits either smooth (S) or rough (R) morphotypes. The S-to-R transition correlates with inhibition of the synthesis and/or transport of glycopeptidolipids (GPLs) and is associated with an increase of pathogenicity in animal and human hosts. Lsr2 is a small nucleoid-associated protein highly conserved in...

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PMID: 31114557
DOI: 10.3389/fmicb.2019.00905

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