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The role of colony morphotype in shaping gene essentiality in Mycobacteroides abscessus

30 Sept 2025

Abstract excerpt

Changes in bacterial colony morphology are common during chronic human infections and are thought to provide a survival advantage. In the human pathogen Mycobacteroides abscessus (MAB), a unidirectional transition from a smooth (MAB S ) to rough (MAB R ) morphotype frequently occurs during chronic infection. This transition has profound clinical implications, as MAB R induces a heightened proinflammatory...

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PMID: 41026822
DOI: 10.1073/pnas.2500719122

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