Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus.

doi:10.1111/mmi.12387

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Article

Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus.

Molecular microbiology - 1 Nov 2013

Pawlik Alexandre, Garnier Guillaume, Orgeur Mickael, Tong Pin, Lohan Amanda, Le Chevalier Fabien, Sapriel Guillaume, Roux Anne-Laure, Conlon Kevin, Honoré Nadine, Dillies Marie-Agnès, Ma Laurence, Bouchier Christiane, Coppée Jean-Yves, Gaillard Jean-Louis, Gordon Stephen V, Loftus Brendan, Brosch Roland, Herrmann Jean Louis

Abstract excerpt

Mycobacterium abscessus is an emerging pathogen that is increasingly recognized as a relevant cause of human lung infection in cystic fibrosis patients. This highly antibiotic-resistant mycobacterium is an exception within the rapidly growing mycobacteria, which are mainly saprophytic and non-pathogenic organisms. M. abscessus manifests as either a smooth (S) or a rough (R) colony morphotype, which is of clinical...

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PMID: 23998761
DOI: 10.1111/mmi.12387

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