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GplR1, an unusual TetR-like transcription factor in <i>Mycobacterium abscessus</i> , controls the production of cell wall glycopeptidolipids, colony morphology, and virulence

2025-05-08

Abstract excerpt

Mycobacterium abscessus is a major human pathogen, mostly infecting people with pre-existing lung conditions such as cystic fibrosis. The production of glycopeptidolipids (GPL) is a major determinant of virulence of this bacterium, with clinical isolates that lack GPL generally exhibiting more aggressive clinical behavior. The current paradigm is that GPL production is abolished in vivo via irreversible, spontane...

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Literature Corpus work
0cdf51be-0d6c-56f4-84e6-c97b8134ab56
DOI
10.1101/2025.05.07.652718
Open publication

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GplR1, an unusual TetR-like transcription factor in <i>Mycobacterium abscessus</i> , controls the production of cell wall glycopeptidolipids, colony morphology, and virulenceDOI 10.1101/2025.05.07.652718
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