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Article

PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction.

International journal of molecular sciences - 2 Jun 2023

Gou Yusong, Wang Lifei, Zhao Jinhan, Xu Xiaoyi, Xu Hangfei, Xie Fang, Wang Yanjun, Feng Yingmei, Zhang Jing, Zhang Yang

Abstract excerpt

Patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism (I148M) is strongly associated with non-alcoholic steatohepatitis and advanced fibrosis; however, the underlying mechanisms remain largely unknown. In this study, we investigated the effect of PNPLA3-I148M on the activation of hepatic stellate cell line LX-2 and the progression of liver fibrosis. Immunofluorescence staining and...

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Identifiers

PMID: 37298640
DOI: 10.3390/ijms24119681
PMCID: PMC10253263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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