Article

A Deep Survival EWAS approach estimating risk profile based on pre-diagnostic DNA methylation: an application to Breast Cancer time to diagnosis

2022-02-25

Abstract excerpt

Previous studies for cancer biomarker discovery based on pre-diagnostic blood DNA methylation profiles, either ignore the explicit modeling of the time to diagnosis (TTD) as in a survival analysis setting, or provide inconsistent results. This lack of consistency is likely due to the limitations of standard EWAS approaches, that model the effect of DNAm at CpG sites on TTD independently. In this work, we argue tha...

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Literature Corpus work: ceb3d9cc-8047-5cb3-b4c9-2a3c0e0022a5
DOI: 10.1101/2022.02.25.481911

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