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Developing survival prediction models in colorectal cancer using epigenome-wide DNA methylation data from whole blood

6 Sept 2024

Abstract excerpt

While genome-wide association studies are valuable in identifying CRC survival predictors, the benefit of adding blood DNA methylation (blood-DNAm) to clinical features, including the TNM system, remains unclear. In a multi-site population-based patient cohort study of 2116 CRC patients with baseline blood-DNAm, we analyzed survival predictions using eXtreme Gradient Boosting with a 5-fold nested leave-sites-out...

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PMID: 39237753
DOI: 10.1038/s41698-024-00689-5

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