Article

Heart generation via blastocyst complementation in Mesp1/2-deficient mice

2023-11-08

Abstract excerpt

<h4>Summary</h4> Heart transplantation is the only curative option available for patients with advanced heart failure. However, donor organ shortage and graft rejection remain critical challenges in heart transplantation. Blastocyst complementation using pluripotent stem cells (PSCs) can be used to generate organs such as the pancreas and kidneys in animal models with abnormalities in essential developmental gene...

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Literature Corpus work: af73820f-d40e-5d5f-9382-396c930383fd
DOI: 10.1101/2023.11.08.565924

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