Article

Corticosteroids prevent pathological angiogenesis yet compromise reparative vascular remodeling in the retina

2024-06-09

Abstract excerpt

Tissue inflammation is often broadly associated with cellular damage, yet sterile inflammation also plays critical roles in beneficial tissue remodeling. In the central nervous system (CNS), this is observed through a predominantly innate immune response in retinal vascular diseases such as age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity. Here we set out to elucidate the dynam...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce7453bb-be44-5b0e-8299-dfbde2fd8e97
DOI: 10.1101/2024.06.06.597805

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Corticosteroids prevent pathological angiogenesis yet compromise reparative vascular remodeling in the retinaDOI 10.1101/2024.06.06.597805Read

Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal InjuriesSemantic proximity Read

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.Semantic proximity Read

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative DiseasesSemantic proximity Read

Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF.Semantic proximity Read

Immunological Landscape of Retinal Ischemia-Reperfusion Injury: Insights into Resident and Peripheral Immune Cell ResponsesSemantic proximity Read

CCR1 Signaling as a Common Injury Pathway in Retinal DegenerationSemantic proximity Read

The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration.Semantic proximity Read

Angiogenesis and Eye DiseaseSemantic proximity Read

Dynamic interplay of innate and adaptive immunity during sterile retinal inflammation: Insights from the transcriptomeSemantic proximity Read

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice.Semantic proximity Read

Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisationSemantic proximity Read

Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.Semantic proximity Read