Article
Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF.
Oncotarget - 16 May 2017
Ridano Magali E, Subirada Paula V, Paz María C, Lorenc Valeria E, Stupirski Juan C, Gramajo Ana L, Luna José D, Croci Diego O, Rabinovich Gabriel A, Sánchez María C
Abstract excerpt
Neovascular retinopathies are leading causes of irreversible blindness. Although vascular endothelial growth factor (VEGF) inhibitors have been established as the mainstay of current treatment, clinical management of these diseases is still limited. As retinal impairment involves abnormal neovascularization and neuronal degeneration, we evaluated here the involvement of galectin-1 in vascular and non-vascular...
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