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Article

The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration.

Proceedings of the National Academy of Sciences of the United States of America - 25 May 2021

Leach Lyndsay L, Hanovice Nicholas J, George Stephanie M, Gabriel Ana E, Gross Jeffrey M

Abstract excerpt

Loss of the retinal pigment epithelium (RPE) because of dysfunction or disease can lead to blindness in humans. Harnessing the intrinsic ability of the RPE to self-repair is an attractive therapeutic strategy; however, mammalian RPE is limited in its regenerative capacity. Zebrafish possess tremendous intrinsic regenerative potential in ocular tissues, including the RPE, but little is known about the mechanisms...

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Source

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Identifiers

PMID: 34006636
DOI: 10.1073/pnas.2017198118
PMCID: PMC8166181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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