Article

Immortalization of different breast epithelial cell types results in distinct mitochondrial mutagenesis

2019-03-30

Abstract excerpt

Different phenotypes of normal cells might influence genetic profiles, epigenetic profiles, and tumorigenicities of their transformed derivatives. In this study, we investigated whether the whole mitochondrial genome of immortalized cells can be attributed to different phenotypes (stem vs non-stem) of their normal epithelial cell originators. To accurately determine mutations, we employed Duplex Sequencing, which...

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Literature Corpus work: ce6ff4be-02b7-5de7-b78e-4d4bcda41be6
DOI: 10.1101/592832

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