Article

Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis

2023-10-17

Abstract excerpt

Patients with triple-negative breast cancer (TNBC) have an increased propensity to develop lung metastasis. Our previous studies demonstrated that stem-like ALDH hi CD44 + breast cancer cells interact with lung-derived soluble factors, resulting in enhanced migration and lung metastasis particularly in TNBC models. We have also observed that the presence of a primary TNBC tumor can ‘prime’ the lung microenvironmen...

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Literature Corpus work: ce64d2ea-11a9-5ed6-aa16-a29f54d6c778
DOI: 10.21203/rs.3.rs-3444133/v1

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