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CD44 is functionally crucial for driving lung cancer stem cells metastasis through Wnt/β‐catenin‐FoxM1‐Twist signaling

1 Dec 2015

Abstract excerpt

A novel paradigm in tumor biology suggests that non‐small cell lung cancer (NSCLC) metastasis is driven by lung cancer stem cell‐like cells (LCSCs), but the underlying mechanisms remain unclear. Here, we aim to investigate biological function of CD44 in regulating metastatic trait of LCSCs and its underlying mechanisms. In this study, we found that CD133+CD44+ cells which were derived from primary lung...

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PMID: 26621583
DOI: 10.1002/mc.22443

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