Article
Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature.
British journal of cancer - 25 Jun 2013
D'Amico L, Patanè S, Grange C, Bussolati B, Isella C, Fontani L, Godio L, Cilli M, D'Amelio P, Isaia G, Medico E, Ferracini R, Roato I
Abstract excerpt
BACKGROUND: Bone metastases represent a common and severe complication in breast cancer, and the involvement of cancer stem cells (CSCs) in the promotion of bone metastasis is currently under discussion. Here, we used a human-in-mice model to study bone metastasis formation due to primary breast CSCs-like colonisation. METHODS: Primary CD44⁺CD24⁻ breast CSCs-like were transduced by a luciferase-lentiviral vector...
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