Article

Murine <i>MPDZ</i> -Linked Hydrocephalus is Caused by Hyperpermeability of the Choroid Plexus

2018-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Though congenital hydrocephalus is heritable, it has been linked only to eight genes, one of which is MPDZ . Humans and mice that carry a truncated version of MPDZ incur severe hydrocephalus resulting in acute morbidity and lethality. We show by magnetic resonance imaging that contrast-medium penetrates into the brain ventricles of mice carrying a Mpdz loss-of-function mutation, whereas none i...

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Literature Corpus work: 10a48b56-220e-51c0-bfe2-4539b71e7818
DOI: 10.1101/446500

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