Article

Targeting GSK-beta with Peptide Inhibitors: A Rational Computational Strategy for Alzheimer's Disease Intervention

2024-12-30

Abstract excerpt

Abstract Glycogen synthase kinase-3 beta is a pivotal serine/threonine kinase implicated in Alzheimers disease (AD) pathogenesis, particularly through the hyperphosphorylation of tau protein and increased production of amyloid-beta (Abeta) peptides. This study investigates kappa casein-derived peptides as potential inhibitors of GSK-3beta. A peptide library of 42 sequences was generated from kappa casein and docki...

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Literature Corpus work: b540c143-3b92-5327-96b8-28491f4fa01e
DOI: 10.1101/2024.12.30.630755

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