Article

Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal Parvalbumin interneurons

2024-06-17

Abstract excerpt

Parkinson’s disease-associated, activating mutations in LRRK2 kinase block primary cilia formation in cell culture and in specific cell types in the brain. In the striatum that is important for movement control, about half of astrocytes and cholinergic interneurons, but not the predominant medium spiny neurons, lose their primary cilia. Here we show that Parvalbumin interneurons that are inhibitory regulators of m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce2f289b-b3a8-5f7c-b66c-a3221af9bd42
DOI: 10.1101/2024.06.17.599289

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal Parvalbumin interneuronsDOI 10.1101/2024.06.17.599289Read

Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal parvalbumin interneurons.Semantic proximity Read

Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s diseaseSemantic proximity Read

Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease.Semantic proximity Read

Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neuronsSemantic proximity Read

Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinsons linked-LRRK2 mutant miceSemantic proximity Read

Lysosomal Glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway to Parkinson’s diseaseSemantic proximity Read

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brainSemantic proximity Read

Selective loss of Primary Cilia and Neurotrophic Signaling in G51D α-Synuclein Mice Highlights a Common Pathway to Parkinson’s DiseaseSemantic proximity Read

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brainSemantic proximity Read

<i>Tet2</i> loss suppress α-synuclein pathology by stimulating ciliogenesisSemantic proximity Read

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neuronsSemantic proximity Read

Differentiation of ciliated human midbrain-derived LUHMES neuronsSemantic proximity Read