Article

Selective loss of Primary Cilia and Neurotrophic Signaling in G51D α-Synuclein Mice Highlights a Common Pathway to Parkinson’s Disease

2026-02-25

Abstract excerpt

Parkinson’s disease is characterized by dopaminergic neuron loss and accumulation of α-synuclein aggregates in the brain. G51D α-synuclein knock-in mice provide a genetically and clinically relevant model of disease, exhibiting early olfactory deficits, age-dependent motor impairment, and progressive phospho-α-synuclein accumulation. In multiple Parkinson’s disease models, striatal cholinergic and parvalbumin inte...

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Literature Corpus work: 5e0a7779-6d81-5b9f-9bbd-31f420cf4ce2
DOI: 10.64898/2026.02.25.708014

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