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Article

Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2024

Khan Shahzad S, Jaimon Ebsy, Lin Yu-En, Nikoloff Jonas, Tonelli Francesca, Alessi Dario R, Pfeffer Suzanne R

Abstract excerpt

Activating leucine-rich repeat kinase 2 (LRRK2) mutations cause Parkinson's and phosphorylation of Rab10 by pathogenic LRRK2 blocks primary ciliogenesis in cultured cells. In the mouse brain, LRRK2 blockade of primary cilia is highly cell type specific: For example, cholinergic interneurons and astrocytes but not medium spiny neurons of the dorsal striatum lose primary cilia in LRRK2-pathway mutant mice. We show...

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Source

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Identifiers

PMID: 39088390
DOI: 10.1073/pnas.2402206121
PMCID: PMC11317616

Genes

CNTN5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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