Article

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons

2019-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Primary cilia are vital signaling organelles that extend from most types of cells, including neurons and glia. However, their function, particularly on neurons in the adult brain, remains largely unknown. Tau tubulin kinase 2 (TTBK2) is a critical regulator of ciliogenesis, and is also mutated a hereditary neurodegenerative disorder, spinocerebellar ataxia type 11 (SCA11). Here, we show that con...

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Literature Corpus work: 58154849-e253-5103-b1b8-a3b98b7050d3
DOI: 10.1101/689448

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