Article

Lysosomal Glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway to Parkinson’s disease

2025-01-21

Abstract excerpt

<h4>SUMMARY</h4> Mutations in LRRK2 and GBA1 are the most common genetic causes of familial Parkinson’s disease. Previously, we showed that pathogenic LRRK2 mutations inhibit primary cilia formation in rare interneurons and astrocytes of the mouse and human dorsal striatum. This blocks Hedgehog signaling and reduces synthesis of neuroprotective GDNF and NRTN, which support neurons vulnerable in PD. Here we sho...

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Literature Corpus work: 4fcffa96-d234-5b63-9524-834f444baacb
DOI: 10.1101/2025.01.20.633968

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