Article
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.
Genes & development - 1 Jul 2018
Zhang Yingying, Burberry Aaron, Wang Jin-Yuan, Sandoe Jackson, Ghosh Sulagna, Udeshi Namrata D, Svinkina Tanya, Mordes Daniel A, Mok Joanie, Charlton Maura, Li Quan-Zhen, Carr Steven A, Eggan Kevin
Abstract excerpt
While a mutation in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS), much remains to be learned concerning the function of the protein normally encoded at this locus. To elaborate further on functions for C9ORF72, we used quantitative mass spectrometry-based proteomics to identify interacting proteins in motor neurons and found that its long isoform complexes with and...
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