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Article

<i>C9orf72</i> is required for proper macrophage and microglial function in mice

18 Mar 2016

Abstract excerpt

Expansions of a hexanucleotide repeat (GGGGCC) in the noncoding region of the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Decreased expression of C9orf72 is seen in expansion carriers, suggesting that loss of function may play a role in disease. We found that two independent mouse lines lacking the C9orf72 ortholog (3110043O21Rik) in all...

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PMID: 26989253
DOI: 10.1126/science.aaf1064

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