Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.

Molecular biology of the cell - 15 Oct 2016

Amick Joseph, Roczniak-Ferguson Agnes, Ferguson Shawn M

Abstract excerpt

Hexanucleotide expansion in an intron of the C9orf72 gene causes amyotrophic lateral sclerosis and frontotemporal dementia. However, beyond bioinformatics predictions that suggested structural similarity to folliculin, the Birt-Hogg-Dubé syndrome tumor suppressor, little is known about the normal functions of the C9orf72 protein. To address this problem, we used genome-editing strategies to investigate C9orf72...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to C9orf72 Protein
Share to Biophysical Phenomena
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Lysosomes

Share to Mechanistic Target of Rapamycin Complex 1

Share to Multiprotein Complexes

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 27559131
DOI: 10.1091/mbc.E16-01-0003
PMCID: PMC5063613

Genes

SMCR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.PMID 27559131Read ↗

C9orf72: At the intersection of lysosome cell biology and neurodegenerative diseaseSemantic proximity Read ↗

Cellular and physiological functions of C9ORF72 and implications for ALS/FTD.Semantic proximity Read ↗

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathwaySemantic proximity Read ↗

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagySemantic proximity Read ↗

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling.Semantic proximity Read ↗

WDR41 supports lysosomal response to changes in amino acid availability.Semantic proximity Read ↗

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.Semantic proximity Read ↗

Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architectureSemantic proximity Read ↗

Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse modelsSemantic proximity Read ↗

C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.Semantic proximity Read ↗

C9orf72 associates with inactive Rag GTPases and regulates mTORC1‐mediated autophagosomal and lysosomal biogenesisSemantic proximity Read ↗

ALS-linked C9orf72–SMCR8 complex is a negative regulator of primary ciliogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.