Article

Integrating genomic data into test-negative designs for estimating lineage-specific COVID-19 vaccine effectiveness

2025-07-11

Abstract excerpt

<h4>Background</h4> SARS-CoV-2 lineage-specific COVID-19 vaccine effectiveness (VE) studies can inform decision-making on whether vaccine composition updates are needed to maintain effectiveness against severe disease as SARS-CoV-2 continues to evolve. Lineage assignment methods in VE test-negative design (TND) studies include sequence-based (whole-genome sequencing), proxy-based (e.g., S-gene target failure duri...

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Literature Corpus work: ce2519a1-dd66-587b-8755-1ac35d82e82f
DOI: 10.1101/2025.07.10.25331291

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