Article

Potential Test-Negative Design Study Bias in Outbreak Settings: Application to Ebola vaccination in Democratic Republic of Congo

2020-01-10

Abstract excerpt

<h4>Background</h4> Infectious disease outbreaks present unique challenges to study designs for vaccine evaluation. Test-negative design (TND) studies have previously been used to estimate vaccine effectiveness and have been proposed for Ebola virus disease (EVD) vaccines. However, there are key differences in how cases and controls are recruited during outbreaks and pandemics of novel pathogens that have implicat...

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Literature Corpus work: 2ac26f00-7447-5e6c-ba53-36b889d23e53
DOI: 10.1101/2020.01.06.20016576

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