Article

Power and sample size considerations for test-negative design with bias correction: a case study on the world first malaria vaccine

2025-03-13

Abstract excerpt

<h4>Background</h4> Test-negative design (TND) studies are increasingly common in evaluating vaccine effectiveness (VE) for various infectious diseases. TND studies are susceptible to bias due to disease outcome misclassification caused by imperfect test sensitivity and specificity. Several bias correction methods have been proposed. However, sample size or power considerations for TND studies incorporating bias c...

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Literature Corpus work: 0b21f8c0-2bfa-55d3-940d-cdec5c4b262d
DOI: 10.1101/2025.03.12.25323823

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