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Article

Estimation and Hypothesis Testing of Strain-Specific Vaccine Efficacy With Missing Strain Types With Application to a COVID-19 Vaccine Trial.

Statistics in medicine - 15 Mar 2025

Heng Fei, Sun Yanqing, Li Li, B Gilbert Peter

Abstract excerpt

Based on data from a randomized, controlled vaccine efficacy trial, this article develops statistical methods for assessing vaccine efficacy (VE) to prevent COVID-19 infections by a discrete set of genetic strains of SARS-CoV-2. Strain-specific VE adjusting for possibly time-varying covariates is estimated using augmented inverse probability weighting to address missing viral genotypes under a competing risks...

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PMID: 40072429
DOI: 10.1002/sim.10345
PMCID: PMC11906172

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