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How Important Are Study Designs? A Simulation Assessment of Vaccine Effectiveness Estimation Bias with Time-Varying Vaccine Coverage, and Heterogeneous Testing and Baseline Attack Rates

2022-08-30

Abstract excerpt

<h4>Objective</h4> We studied how commonly used vaccine effectiveness (VE) study designs (variations of cohorts, and test-negative designs) perform under epidemiological nuances more prominent in the COVID-19 era, specifically time-varying vaccine coverage, and heterogeneous testing behaviour and baseline attack rates with selection on willingness to vaccinate. <h4>Methodology</h4> We simulated data from a multi-p...

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Literature Corpus work: 1d885a0f-7c8c-552e-b09c-11aa23751626
DOI: 10.1101/2022.08.25.22279235

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