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In situ programming of intratumoural stem cell-like memory CD8⁺ T cells enables durable antitumour immunity in immunosuppressive tumours

2026-02-07

Abstract excerpt

Tumours with an immunosuppressive microenvironment often respond poorly to radiotherapy (RT) and immune checkpoint inhibitors, and durable clinical responses remain rare. These failures are not solely explained by insufficient immune activation, but instead reflect an inability of current therapies to establish CD8⁺ T-cell infiltration and states required for long-term tumour control. Although stem cell-like memor...

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Literature Corpus work
ce228ff7-b7d2-5dfb-90da-29140f29b651
DOI
10.64898/2026.02.06.700840
Open publication

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In situ programming of intratumoural stem cell-like memory CD8⁺ T cells enables durable antitumour immunity in immunosuppressive tumoursDOI 10.64898/2026.02.06.700840
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