Article

FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterations

2023-02-24

Abstract excerpt

<h4>ABSTRACT</h4> FUS (Fused in sarcoma) is a ubiquitously expressed DNA/RNA binding protein. Mutations in FUS cause aggressive juvenile forms of amyotrophic lateral sclerosis (ALS), as in the case with the FUSDelta14 mutation. While most studies have focused on the role of FUS in motor neuron degeneration, little is known about the effect of FUS mutations in the whole body, and the impact of FUS mutations in t...

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Literature Corpus work: ce0d44b4-6d71-5262-a770-61a8e8407eb8
DOI: 10.1101/2023.02.24.529858

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