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Deconstructing the Thymic Microenvironment Through Genesis to Senescence

25 Jun 2025

Abstract excerpt

The thymus is essential for adaptive immunity, orchestrating the differentiation of hematopoietic progenitors into various T-cell lineages. Thymic epithelial cells (TECs) impart this unique function by mediating the major checkpoints in T-cell differentiation while also imposing stringent tolerance processes required to prevent autoimmunity. Achieving these feats requires extensive TEC specialization and the...

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PMID: 40558001
DOI: 10.1111/imr.70048

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