Article

NicheNet-Based Dissection of CD14 <sup>+</sup> Monocyte Crosstalk with Memory CD4 <sup>+</sup> T Cells in Human PBMCs

2025-08-31

Abstract excerpt

Intercellular communication between monocytes and T cells is essential for immune regulation within peripheral blood mononuclear cells (PBMCs). To examine how CD14 + monocytes regulate memory CD4 + T cells at the gene expression level, we applied NicheNet to PBMC single-cell RNA-seq data. We performed quality control, normalization, principal component analysis, and UMAP-based visualization. CD14 + monocytes an...

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Literature Corpus work: ce09288d-1a5c-5a3e-af85-9dda07505c02
DOI: 10.1101/2025.08.26.672385

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