Article

Genomic and phenotypic stability of fusion-driven pediatric Ewing sarcoma cell lines

2023-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Human cancer cell lines are the mainstay of cancer research. Recent reports showed that highly mutated adult carcinoma cell lines (mainly HeLa and MCF-7) present striking diversity across laboratories and that long-term continuous culturing results in genomic/transcriptomic heterogeneity with strong phenotypical implications. This highlighted how despite human cell line models being powerful too...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cdf4cc68-17ca-54df-9bc5-437e4e2cfadb
DOI: 10.1101/2023.11.20.567802

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic and phenotypic stability of fusion-driven pediatric Ewing sarcoma cell linesDOI 10.1101/2023.11.20.567802Read

Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines.Semantic proximity Read

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulationSemantic proximity Read

Ewing and Ewing-like-sarcoma tumoroid biobank reveals distinct drug sensitivities: translocation makes the differenceSemantic proximity Read

Multidirectional Cellular Plasticity in Ewing Sarcoma Reveals a Tumor–CAF Continuum and Novel Immunotherapeutic TargetsSemantic proximity Read

Genomic fidelity and evolution of cancer patient-derived organoidsSemantic proximity Read

The secret lives of cancer cell linesSemantic proximity Read

Future Match Making: When Pediatric Oncology Meets Organoid TechnologySemantic proximity Read

Single-cell transcriptional profiling reveals heterogeneity and developmental trajectories of Ewing sarcomaSemantic proximity Read

Cancer Cell Lines Are Useful Model Systems for Medical ResearchSemantic proximity Read

Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells.Semantic proximity Read

Physiologically refined cell culture conditions uncover oncogene-dependent metabolic signatures in Ewing sarcoma spheroidsSemantic proximity Read

Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcomaSemantic proximity Read