Article
Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines.
Nature communications - 3 Jan 2025
Kasan Merve, Geyer Florian H, Siebenlist Jana, Sill Martin, Öllinger Rupert, Faehling Tobias, de Álava Enrique, Surdez Didier, Dirksen Uta, Oehme Ina, Scotlandi Katia, Delattre Olivier, Müller-Nurasyid Martina, Rad Roland, Strauch Konstantin, Grünewald Thomas G P, Cidre-Aranaz Florencia
Abstract excerpt
Human cancer cell lines are the mainstay of cancer research. Recent reports showed that highly mutated adult carcinoma cell lines (mainly HeLa and MCF-7) present striking diversity across laboratories and that long-term continuous culturing results in genomic/transcriptomic heterogeneity with strong phenotypical implications. Here, we hypothesize that oligomutated pediatric sarcoma cell lines mainly driven by a...
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