Article
Stem-loop binding protein is required for retinal cell proliferation, neurogenesis, and intraretinal axon pathfinding in zebrafish.
Developmental biology - 1 Oct 2014
Imai Fumiyasu, Yoshizawa Asuka, Matsuzaki Ayako, Oguri Eri, Araragi Masato, Nishiwaki Yuko, Masai Ichiro
Abstract excerpt
In the developing retina, neurogenesis and cell differentiation are coupled with cell proliferation. However, molecular mechanisms that coordinate cell proliferation and differentiation are not fully understood. In this study, we found that retinal neurogenesis is severely delayed in the zebrafish stem-loop binding protein (slbp) mutant. SLBP binds to a stem-loop structure at the 3'-end of histone mRNAs, and...
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