Article

Functional Genomic Screens Reveal RBBP4 as a Key Regulator of Cell Cycle Progression in TMZ-Resistant Glioblastoma

2025-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Temozolomide (TMZ) remains the standard of care for glioblastoma; however, its efficacy is frequently influenced by epigenetic mechanisms, notably the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter. While MGMT promoter hypermethylation is associated with enhanced responsiveness to TMZ, additional epigenetic determinants of TMZ resistance remain largely undefined...

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Literature Corpus work: 98a81f84-81ae-5acb-9b4d-0033f5d9f2fb
DOI: 10.1101/2025.05.09.653010

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