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Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice

2021-02-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Rigorous preclinical studies of chimeric antigen receptor (CAR) immunotherapy will require large quantities of consistent and high-quality CAR-transduced T (CART)-cells that can be used in syngeneic mouse glioblastoma (GBM) models. To this end, we developed a novel transgenic (Tg) mouse strain with a fully murinized CAR targeting epidermal growth factor receptor variant III...

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Literature Corpus work
cdcc1c5a-d5eb-5a42-8d3f-9cc38bca5c97
DOI
10.1101/2021.01.31.429020
Open publication

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Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic miceDOI 10.1101/2021.01.31.429020
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