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Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma

2024-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor (CAR) T cells have shown significant efficacy in hematological diseases. However, CAR T therapy has demonstrated limited efficacy in solid tumors, including glioblastoma (GBM). One of the most important reasons is the immunosuppressive tumor microenvironment (TME), which promotes tumor growth and suppresses immune cells to eliminate tumor cells. The human transforming g...

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Literature Corpus work
11cbf678-3877-5923-b052-ea7ffa2ad0e8
DOI
10.1101/2024.02.26.582107
Open publication

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