Article

Single Cell Transcriptomic Modelling of the Fallopian Tube Epithelium Identifies Cellular Specialisation, Novel Differentiation Trajectories, and Gene Network Associations with Ectopic Pregnancy

2024-12-20

Abstract excerpt

<h4>STUDY QUESTION</h4> Can network modelling of single cell transcriptomic data identify cellular developmental trajectories of fallopian tube (FT) epithelium and reveal functional and pathological divergence from the endometrium? <h4>SUMMARY ANSWER</h4> A bidirectional secretory and ciliated differentiation trajectory was apparent from a novel OVGP1+ progenitor population of FT epithelial cells. A causal netwo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c27a87f-79ff-585e-b2c2-83408ed9c708
DOI: 10.1101/2024.12.20.629653

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single Cell Transcriptomic Modelling of the Fallopian Tube Epithelium Identifies Cellular Specialisation, Novel Differentiation Trajectories, and Gene Network Associations with Ectopic PregnancyDOI 10.1101/2024.12.20.629653Read

Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tubeSemantic proximity Read

Single-cell Transcriptomics Identifies Gene Expression Networks Driving Differentiation and Tumorigenesis in the Human Fallopian TubeSemantic proximity Read

Integrated Human Transcriptomics Identifies Fallopian Tube Progenitors as Plausible Precursors of High-Grade Serous Ovarian CancerSemantic proximity Read

A Cellular atlas of the human fallopian tube reveals the metamorphosis of secretory epithelial cells during the menstrual cycle and menopauseSemantic proximity Read

Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal womenSemantic proximity Read

Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichmentSemantic proximity Read

Single cell transcriptomes of normal endometrial derived organoids uncover novel cell type markers and cryptic differentiation of primary tumoursSemantic proximity Read

Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived OrganoidsSemantic proximity Read

Using advanced spatial and single-cell transcriptomics to characterize the human endometriumSemantic proximity Read

A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencingSemantic proximity Read

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitroSemantic proximity Read