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Single-cell mapping of the fallopian tube reveals a genomically unstable secretory cell state enriched in carriers of germline <i>BRCA1/2</i> mutations

2026-08-27

Abstract excerpt

Carriers of germline BRCA1 or BRCA2 alterations have a substantially increased lifetime risk of high-grade serous ovarian carcinoma (HGSOC), which originates from the secretory cells of the fallopian tube. However, comparative multi-omic analyses of bulk fallopian tube tissue from BRCA1/2 carriers and the general population have, to date, revealed only limited differences. New molecular biomarkers of early mali...

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Literature Corpus work
5710ee07-5c6e-5d02-ae0c-9381ce6cdbaa
DOI
10.64898/2026.08.26.746998
Open publication

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Single-cell mapping of the fallopian tube reveals a genomically unstable secretory cell state enriched in carriers of germline <i>BRCA1/2</i> mutationsDOI 10.64898/2026.08.26.746998
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