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Article

Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors.

Cell reports - 19 Oct 2021

Todd Levi, Hooper Marcus J, Haugan Alexandra K, Finkbeiner Connor, Jorstad Nikolas, Radulovich Nicholas, Wong Claire K, Donaldson Phoebe C, Jenkins Wesley, Chen Qiang, Rieke Fred, Reh Thomas A

Abstract excerpt

Regenerative neuroscience aims to stimulate endogenous repair in the nervous system to replace neurons lost from degenerative diseases. Recently, we reported that overexpressing the transcription factor Ascl1 in Müller glia (MG) is sufficient to stimulate MG to regenerate functional neurons in the adult mouse retina. However, this process is inefficient, and only a third of the Ascl1-expressing MG generate new...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34686336
DOI: 10.1016/j.celrep.2021.109857
PMCID: PMC8691131

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