Article

Robust reprogramming of glia into neurons by inhibition of Notch signaling and NFI factors in adult mammalian retina

2023-11-01

Abstract excerpt

<h4>Summary</h4> Generation of neurons through direct reprogramming has emerged as a promising therapeutic approach for neurodegenerative diseases. Despite successful applications in vitro , in vivo implementation has been hampered by low efficiency. In this study, we present a highly efficient strategy for reprogramming retinal glial cells into neurons by simultaneously inhibiting key negative regulators. By s...

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Literature Corpus work: 68f50281-ce71-5f66-b01d-612f7f1a1511
DOI: 10.1101/2023.10.29.560483

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