Article
Retinal remodeling triggered by photoreceptor degenerations.
The Journal of comparative neurology - 8 Sept 2003
Jones Bryan W, Watt Carl B, Frederick Jeanne M, Baehr Wolfgang, Chen Ching-Kang, Levine Edward M, Milam Ann H, Lavail Matthew M, Marc Robert E
Abstract excerpt
Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It has long been assumed that the surviving neural retina is largely resistant to this sensory deafferentation. New evidence from fast retinal degenerations reveals that subtle plasticities in neuronal form and connectivity emerge early in disease. By screening mature natural, transgenic, and knockout retinal degeneration...
Topics
- Aging
- Amino Acids
- Animals
- Animals, Genetically Modified
- Cell Death
- Cell Movement
- Disease Models, Animal
- Glutathione
- Humans
- Image Processing, Computer-Assisted
- Immunohistochemistry