Article

Unusually Rapid Isomerization of Aspartic Acid in Tau

2024-12-05

Abstract excerpt

Spontaneous chemical modifications in long-lived proteins can potentially change protein structure in ways that impact proteostasis and cellular health. For example, isomerization of aspartic acid interferes with protein turnover and is anticorrelated with cognitive acuity in Alzheimer’s disease. However, few isomerization rates have been determined for Asp residues in intact proteins. To remedy this deficiency, w...

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Literature Corpus work: cd932872-f10b-5602-8bb9-d439c7ba6ad4
DOI: 10.1101/2024.12.04.626870

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