Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells.

Cells - 16 Feb 2021

Kern Ursula, Fröhlich Klemens, Bedacht Johanna, Schmidt Nico, Biniossek Martin L, Gensch Nicole, Baerenfaller Katja, Schilling Oliver

Abstract excerpt

DJ-1 is an abundant and ubiquitous component of cellular proteomes. DJ-1 supposedly exerts a wide variety of molecular functions, ranging from enzymatic activities as a deglycase, protease, and esterase to chaperone functions. However, a consensus perspective on its molecular function in the cellular context has not yet been reached. Structurally, the C-terminal helix 8 of DJ-1 has been proposed to constitute a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to Lysosomes
Share to Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oxidative Stress

Share to Parkinson Disease

Share to Peptide Hydrolases

Share to Protein Deglycase DJ-1

Share to Proteome

Source

Open in PubMed Open full text

Identifiers

PMID: 33669258
DOI: 10.3390/cells10020404
PMCID: PMC7920061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells.PMID 33669258Read ↗

Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage.Semantic proximity Read ↗

Structural Biology of the DJ-1 Superfamily.Semantic proximity Read ↗

Novel Redox-Dependent Esterase Activity (EC 3.1.1.2) for DJ-1: Implications for Parkinson's Disease.Semantic proximity Read ↗

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD modelSemantic proximity Read ↗

The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological ResearchSemantic proximity Read ↗

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease modelSemantic proximity Read ↗

Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1.Semantic proximity Read ↗

The <i>Drosophila</i> metallopeptidase <i>superdeath</i> decouples apoptosis from the activation of the ER stress responseSemantic proximity Read ↗

C Terminus of DJ-1 Determines Its Homodimerization, Deglycation Activity and Suppression of FerroptosisSemantic proximity Read ↗

L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments.Semantic proximity Read ↗

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy MetabolismSemantic proximity Read ↗

Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.